PhD defence M.A. (Martine) Aardoom

Predicting Outcomes in Pediatric Inflammatory Bowel Disease

On 10 May 2022, M.A. Aardoom will defend her PhD dissertation, entitled: ‘Predicting Outcomes in Pediatric Inflammatory Bowel Disease’.

Promotor
Prof.dr. J.C. Escher
Promotor
Prof.dr. J.N. Samsom
Co-promotor
Dr. L. de Ridder
Date
Tuesday 10 May 2022, 13:00 - 14:30
Type
PhD defence
Space
Professor Andries Querido room
Building
Education Center
Location
Erasmus MC
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Dissertation in short:

Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract that is generally classified as Crohn’s disease (CD) or ulcerative colitis (UC). If the diagnosis is made during childhood or adolescence (paediatric-onset IBD), approximately two third has CD. Given it is a life-long disease, the disease may have consequences on the child’s physical and mental development. Paediatric-onset IBD (PIBD) has a relapsing and remitting pattern and is very heterogeneous. The disease course of an individual child with IBD can currently not be predicted. Therefore, in general, there are two treatment strategies; one for children with CD and one for children with UC. Ineffective treatment strategies negatively affect the disease course of children with IBD.

The aim of this thesis was to gain knowledge on predictors of disease course in children with IBD, and to identify children who are at-risk of developing complications. Additionally, new treatment strategies, guided towards a more individualized treatment strategy were investigated and optimized.

More information

The public defence will begin exactly at 13.00 hrs. The doors will be closed once the public defence starts, latecomers can access the hall via the fourth floor. Due to the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony.

A live stream link has been provided to the candidate.

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