On Tuesday, 28 June 2022, T. van Schaik will defend his PhD dissertation, entitled: ‘Dams in the Nucleus. The dynamics of heterochromatin positioning at nuclear structures in the mammalian nucleus’.
- Promotor
- Co-promotor
- Date
- Tuesday 28 Jun 2022, 13:00 - 14:30
- Type
- PhD defence
- Space
- Professor Andries Querido room
- Building
- Education Center
- Location
- Erasmus MC
Dissertation in short:
Genome organization and gene regulation are important contributors to cell identity and normal behavior, but remain poorly understood. In this PhD thesis, I have studied how the genome is organized around nuclear substructures, such as the nuclear lamina and nucleoli, and what the functional role is of this organization. To do this, I have developed a new experimental methodology to profile where these structures interact with the genome, and used this to test the dynamics during the cell cycle and after various perturbation experiments. Overall, I have identified several factors that modulate nuclear positioning of the genome, and correlated nuclear positioning at the substructures with various functional consequences.
- More information
The public defence will begin exactly at 13.00 hrs. The doors will be closed once the public defence starts, latecomers can access the hall via the fourth floor. Due to the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony.
A live stream link has been provided to the candidate.
