On 31 March 2022, F.J.M. Roos will defend his PhD dissertation, entitled: ‘Studying the Biliary Tree using Organoid-Technology’.
- Promotor
- Promotor
- Co-promotor
- Date
- Tuesday 29 Mar 2022, 08:10 - 08:10
- Type
- PhD defence
- Space
- Senate Hall
- Building
- Erasmus Building
- Location
- Campus Woudestein
Dissertation in short:
Cholangiocyte organoids have emerged as promising new model for studying the bile duct development, regeneration and diseases in vitro. In the studies presented in this thesis, the scientific organoid community was unified and the possibilities to translate in vitro knowledge to improve the outcome of patients with cholangiopathies in the clinic was explored. It was shown that cholangiocyte organoids are suitable for modeling biliary diseases and the importance of the local origin of cholangiocytes was described. In addition, the use of decellularized bile ducts provided the first proof-of-concept that these cells can be used for tissue engineering purposes of the human extrahepatic bile duct in vitro. These constructs have the potential to be successfully transplanted in humans. Together with the regenerative potential of cholangiocyte organoids, this thesis indicates that cholangiocyte organoids can contribute to overcoming the donor supply problem.
- More information
The public defence will begin exactly at 15.30 hrs. The doors will be closed once the public defence starts, latecomers can access the hall via the fourth floor. Due to the solemn nature of the ceremony, we recommend that you do not take children under the age of 6 to the first part of the ceremony.
A live stream link has been provided to the candidate.