On Thursday 20 November 2024, E.O. Cruz López will defend the doctoral thesis titled: Liver Angiotensinogen Suppression: Targeting with Small Interfering RNA, Reversal Mechanisms, and Emerging Therapies in Renin-Angiotensin System Modulation
- Promotor
- Co-promotor
- Date
- Wednesday 20 Nov 2024, 10:30 - 12:00
- Type
- PhD defence
- Space
- Professor Andries Querido room
- Building
- Education Center
- Location
- Erasmus MC
Brief summary:
Hypertension is a major global health concern, significantly contributing to cardiovascular morbidity and mortality. Central to its regulation is the renin-angiotensin system (RAS), with angiotensinogen (AGT) as a pivotal precursor for angiotensin II, a potent vasoconstrictor. This thesis explores the therapeutic potential of liver-targeted small interfering RNA (siRNA) therapies designed to suppress AGT production, offering a novel approach to modulate the RAS and reduce blood pressure. In addition to evaluating the efficacy of AGT suppression, the work investigates the reversal mechanisms involved and compares various anti-hypertensive drug classes and combinations, aiming to identify the most effective strategies for long-term blood pressure control.
- More information
The public defence will begin exactly at 10.30 hrs. The doors will be closed once the public defence starts, latecomers can access the hall via the fourth floor. Due to the solemn nature of the ceremony, children under the age of 6 are not allowed during the first part of the ceremony.
