On Wednesday 26 February 2025, S.M. Ernst will defend the doctoral thesis titled: KRAS Mutations in Non-Small Cell Lung Cancer
- Promotor
- Co-promotor
- Date
- Wednesday 26 Feb 2025, 10:30 - 12:00
- Type
- PhD defence
- Space
- Professor Andries Querido room
- Building
- Education Center
- Location
- Erasmus MC
Below is a brief summary of the dissertation:
With the introduction of immune checkpoint inhibitors (ICIs) and the first Kirsten rat sarcoma virus (KRAS) G12C inhibitors, significant strides have been made in the management of patients with advanced KRAS-mutated non-small cell lung cancer (NSCLC). However, outcomes in this patient population remain modest compared to outcomes in patients with other oncogenic drivers such as epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) alterations. The considerable heterogeneity of KRAS-mutated NSCLC, likely due to its strong association with smoking, presumably contributes to this discrepancy. In this thesis, we aimed to provide insights into integrating novel technologies, such as circulating tumour DNA (ctDNA), and advancements in drug development into daily clinical practice to improve outcomes for patients with KRAS-mutated NSCLC.
- More information
The public defence will start exactly at 10.30 hrs. The doors will be closed once the public defence starts, latecomers can access the hall via the fourth floor. Given the solemn nature of the meeting, we advise not to bring children under the age of 6 to the first part of the ceremony.
A livestream link has been provided to candidate.
