dr. EAW (Eric) Slob, MSc

Biography

I develop methods and techniques for big (genetic) datasets. In my work, I use genetic evidence to answer research questions in social science and medicine. I am funded by the sectorplan SSH-Breed.

Erasmus School of Social and Behavioural Sciences

Assistant professor | Methods & Skills

Email: e.slob@essb.eur.nl

Pure profile

Work

Alisha Aman, Eric A.W. Slob, Joey Ward, Naveed Sattar & Rona J. Strawbridge (2024) - Investigating the association of the effect of genetically proxied PCSK9i with mood disorders using cis-pQTLs: A drug-target Mendelian randomization study - PLoS ONE, 19 (9) - doi: 10.1371/journal.pone.0310396 - [link]
Maddalena Ardissino, Buu Truong, Eric A.W. Slob, Art Schuermans, Satoshi Yoshiji, Alec P. Morley, Stephen Burgess, Fu Siong Ng, Antonio De Marvao, Pradeep Natarajan, Kypros Nicolaides, Liam Gaziano, Adam Butterworth & Michael C. Honigberg (2024) - Proteome- and Transcriptome-Wide Genetic Analysis Identifies Biological Pathways and Candidate Drug Targets for Preeclampsia - Circulation: Genomic and Precision Medicine, 17 (5), e004755 - doi: 10.1161/CIRCGEN.124.004755 - [link]
Maddalena Ardissino, Eric A W Slob, Rohin K Reddy, Alec P Morley, Art Schuermans, Phoebe Hill, Catherine Williamson, Michael C Honigberg, Antonio de Marvao & Fu Siong Ng (2024) - Genetically proxied low-density lipoprotein cholesterol lowering via PCSK9-inhibitor drug targets and risk of congenital malformations - European Journal of Preventive Cardiology, 31 (8), 955-965 - doi: 10.1093/eurjpc/zwad402 - [link]
Maddalena Ardissino, Alec P Morley, Eric A W Slob, Art Schuermans, Bilal Rayes, Zahra Raisi-Estabragh, Antonio de Marvao, Stephen Burgess, Tormod Rogne, Michael C Honigberg & Fu Siong Ng (2024) - Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association - European Heart Journal, 45 (6), 443-454 - doi: 10.1093/eurheartj/ehad631 - [link]
Art Schuermans, Buu Truong, Maddalena Ardissino, Rohan Bhukar, Eric A.W. Slob, Tetsushi Nakao, Jacqueline S. Dron, Aeron M. Small, So Mi Jemma Cho, Zhi Yu, Whitney Hornsby, Tajmara Antoine, Kim Lannery, Darina Postupaka, Kathryn J. Gray, Qi Yan, Adam S. Butterworth, Stephen Burgess, Malissa J. Wood, Nandita S. Scott, Colleen M. Harrington, Amy A. Sarma, Emily S. Lau, Jason D. Roh, James L. Januzzi, Pradeep Natarajan & Michael C. Honigberg (2024) - Genetic Associations of Circulating Cardiovascular Proteins With Gestational Hypertension and Preeclampsia - JAMA Cardiology, 9 (3), 209-220 - doi: 10.1001/jamacardio.2023.4994 - [link]
Hans van Kippersluis, Pietro Biroli, Rita Dias Pereira, Titus J. Galama, Stephanie von Hinke, S. Fleur W. Meddens, Dilnoza Muslimova, Eric A.W. Slob, Ronald de Vlaming & Cornelius A. Rietveld (2023) - Overcoming attenuation bias in regressions using polygenic indices - Nature Communications, 14 (1) - doi: 10.1038/s41467-023-40069-4 - [link]
Maddalena Ardissino, Rohin K. Reddy, Eric A.W. Slob, Jack Griffiths, Joanna Girling & Fu Siong Ng (2023) - Maternal hypertensive traits and adverse outcome in pregnancy: A Mendelian randomization study - Journal of Hypertension, 41 (9), 1438-1445 - doi: 10.1097/HJH.0000000000003486 - [link]
Varun Warrier, Eva-Maria Stauffer, Qin Qin Huang, Emilie M. Wigdor, Eric A. W. Slob, Jakob Seidlitz, Lisa Ronan, Sofie L. Valk, Travis T. Mallard, Andrew D. Grotzinger, Rafael Romero-Garcia, Simon Baron-Cohen, Daniel H. Geschwind, Madeline A. Lancaster, Graham K. Murray, Michael J. Gandal, Aaron Alexander-Bloch, Hyejung Won, Hilary C. Martin, Edward T. Bullmore & Richard A. I. Bethlehem (2023) - Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes - Nature Genetics, 55 (9), 1483-1493 - doi: 10.1038/s41588-023-01475-y - [link]
Maddalena Ardissino, Eric A W Slob, Paul Carter, Tormod Rogne, Joanna Girling, Stephen Burgess & Fu Siong Ng (2023) - Sex-Specific Reproductive Factors Augment Cardiovascular Disease Risk in Women: A Mendelian Randomization Study - Journal of the American Heart Association, 12 (5), e027933 - doi: 10.1161/jaha.122.027933 - [link]
Cornelius A. Rietveld, Ronald de Vlaming & Eric A. W. Slob (2023) - The identification of mediating effects using genome-based restricted maximum likelihood estimation - PLoS Genetics, 19 (2) - doi: 10.1371/journal.pgen.1010638
Bilal Rayes, Maddalena Ardissino, Eric A. W. Slob, Kiran Haresh Kumar Patel, Joanna Girling & Fu Siong Ng (2023) - Association of Hypertensive Disorders of Pregnancy With Future Cardiovascular Disease - JAMA network open, 6 (2), e230034 - doi: 10.1001/jamanetworkopen.2023.0034 - [link]
Stephen Burgess, Amy M Mason, Andrew J Grant, Eric A W Slob, Apostolos Gkatzionis, Verena Zuber, Ashish Patel, Haodong Tian, Cunhao Liu, William G Haynes, G Kees Hovingh, Lotte Bjerre Knudsen, John C Whittaker & Dipender Gill (2023) - Using genetic association data to guide drug discovery and development: Review of methods and applications - American Journal of Human Genetics, 110 (2), 195-214 - doi: 10.1016/j.ajhg.2022.12.017 - [link]
Alisha Aman, Eric A. W. Slob, Joey Ward, Breda Cullen, Nicholas Graham, Donald M. Lyall, Naveed Sattar & Rona J. Strawbridge (2022) - Investigating the potential impact of PCSK9-inhibitors on mood disorders using eQTL-based Mendelian randomization - PLoS ONE, 17 (12), e0279381 - doi: 10.1371/journal.pone.0279381 - [link]
Opeyemi Soremekun, Eric A W Slob, Stephen Burgess, Palwende Romuald Boua, Segun Fatumo & Dipender Gill (2022) - Genetically Predicted Lipid Traits, Diabetes Liability, and Carotid Intima-Media Thickness in African Ancestry Individuals: A Mendelian Randomization Study - Circulation. Genomic and precision medicine, 15 (6), e003910 - doi: 10.1161/circgen.122.003910 - [link]
Maddalena Ardissino, Eric A. W. Slob, Skanda Rajasundaram, Rohin K. Reddy, Benjamin Woolf, Joanna Girling, Mark R. Johnson, Fu Siong Ng & Dipender Gill (2022) - Safety of beta-blocker and calcium channel blocker antihypertensive drugs in pregnancy: a Mendelian randomization study - BMC Medicine, 20 (1), 288 - doi: 10.1186/s12916-022-02483-1 - [link]
Ronald De Vlaming, Eric A.W. Slob, Patrick J.F. Groenen & Cornelius A. Rietveld (2022) - Multivariate estimation of factor structures of complex traits using SNP-based genomic relationships - BMC Bioinformatics, 23 (1) - doi: 10.1186/s12859-022-04835-3 - [link]
Verena Zuber, Nastasiya F. Grinberg, Dipender Gill, Ichcha Manipur, Eric A.W. Slob, Ashish Patel, Chris Wallace & Stephen Burgess (2022) - Combining evidence from Mendelian randomization and colocalization: Review and comparison of approaches - American Journal of Human Genetics, 109 (5), 767-782 - doi: 10.1016/j.ajhg.2022.04.001 - [link]
Maddalena Ardissino, Eric A W Slob, Ophelia Millar, Rohin K Reddy, Laura Lazzari, Kiran Haresh Kumar Patel, David Ryan, Mark R Johnson, Dipender Gill & Fu Siong Ng (2022) - Maternal Hypertension Increases Risk of Preeclampsia and Low Fetal Birthweight: Genetic Evidence From a Mendelian Randomization Study - Hypertension, 79 (3), 588-598 - doi: 10.1161/hypertensionaha.121.18617 - [link]
Maddalena Ardissino, Rohin K. Reddy, Eric A.W. Slob, Kiran H.K. Patel, David K. Ryan, Dipender Gill & Fu Siong Ng (2022) - Sleep Disordered Breathing, Obesity and Atrial Fibrillation: A Mendelian Randomisation Study - Genes, 13 (1) - doi: 10.3390/genes13010104 - [link]